A Simple Key For apl11 Unveiled
A Simple Key For apl11 Unveiled
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promyelocytic (M3) acute leukaemia; many clients Categorical an unconventional morphologic spectrum intermediate between M2 and M3 AML.
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significant level of typical or dystrophic promyelocytes in peripheralblood and in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction positive; immunocytochemical detection having an anti-PLZF demonstrates adistinct punctate nuclear distribution of your protein, suggesting itscompartmentalization within the nucleus.
Speedy detection of prognostically important fusion transcripts in acute leukemia applying simplified multiplex reverse transcription polymerase chain response.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a situation report and overview of literature.
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Productive allogeneic bone marrow transplantation in a scenario of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A scenario of acute promyelocytic leukaemia with unusual cytological attributes plus a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation includes a breakpoint in the zinc fingerregion of PLZF, with fusion of two zinc fingers on the RARa B location toform a five PLZF - three RARa fusion gene; the reciprocal five RARa - 3 PLZF genefuses 7 zinc fingers into the RARa region; RARas breakpoint occurs in1- because of thealternative splicing of PLZF gene, two sorts of PLZF-RARa protein is usually detected: